Addressing the challenges of the clinical application of pharmacogenetic testing.
نویسندگان
چکیده
Pharmacogenomics aims to use molecular genetic markers to predict treatment outcome. Indeed, within the past decade there has been a rapid emergence of pharmacogenetic tests to aid clinicians in predicting efficacy or toxicity for some drugs. Despite this major advance in therapeutic drug management, there remain challenges to the appropriate use of pharmacogenetic tests. We discuss UGT1A1 pharmacogenetic testing to illustrate the knowledge gaps impeding widespread use of pharmacogenetic tests in the clinical setting.
منابع مشابه
Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines
Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinion...
متن کاملExploring the Challenges of Physiotherapy Clinical Education: A Qualitative Study
Objectives: Clinical education is an important component of physiotherapy education. The students’ and clinical educators’ viewpoints about different aspects of education are being analyzed worldwide for the promotion of educational services. The aim of this study was to identify the challenges of clinical education based on the experiences of physiotherapy students and educators.&n...
متن کاملI-33: Pharmacogenetics of Reproductive Medicine
Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...
متن کاملPharmacogenetic approaches in the treatment of alcohol use disorders: addressing clinical utility and implementation thresholds
Despite advances in characterizing genetic influences on addiction liability and treatment response, clinical applications of these efforts have been slow to evolve. Although challenges to clinical translation remain, stakeholders already face decisions about evidentiary thresholds for the uptake of pharmacogenetic tests in practice. There is optimism about potential pharmacogenetic application...
متن کاملAddressing NCDs: Penetration of the Producers of Hazardous Products into Global Health Environment Requires a Strong Response; Comment on “Addressing NCDs: Challenges From Industry Market Promotion and Interferences”
Timely warnings and examples of industry interference in relation to tobacco, alcohol, food and breast milk substitutes are given in the editorial by Tangcharoensathien et al. Such interference is rife at national levels and also at the global level. In an era of ‘private public partnerships’ the alcohol and food industries have succeeded in insinuating themselves into the global health environ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Clinical pharmacology and therapeutics
دوره 86 1 شماره
صفحات -
تاریخ انتشار 2009